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DHBP dibromide

CAS No. 6159-05-3

DHBP dibromide( Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO )

Catalog No. M20752 CAS No. 6159-05-3

DHBP dibromide is calcium release and a muscle relaxant inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DHBP dibromide
  • Note
    Research use only, not for human use.
  • Brief Description
    DHBP dibromide is calcium release and a muscle relaxant inhibitor.
  • Description
    DHBP dibromide is calcium release and a muscle relaxant inhibitor.
  • In Vitro
    DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.
  • In Vivo
    ——
  • Synonyms
    Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6159-05-3
  • Formula Weight
    514.38
  • Molecular Formula
    C24H38Br2N2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:30 mg/mL (58.32 mM)
  • SMILES
    [Br-].[Br-].CCCCCCC[n+]1ccc(cc1)-c1cc[n+](CCCCCCC)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Aguilar-Sanchez Y Difranco M Darcy Y L et al. DHBP Reversibly Inhibits Calcium Release from Sarcoplasmic Reticulum (SR) in Skeletal Muscle and Heart[J]. Biophysical Journal 2017 112(3):161a-162a.
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